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Affiliation

  • McGill Centre for Structural Biology (CSB)
  • McGill Canadian Institute of Health Research Training Program in Drug Development (CIHR / IRSC)
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Research

Phosphorus-containing compounds constitute an important class of human therapeutics. Additionally, such compounds are valuable molecular tools in chemical biology and important ligands in enantioselective organic synthesis. The main focus of our research is the design and synthesis of phosphorus-containing heterocyclic compounds, including compounds with a chiral phosphorus center. We are developing synthetic methodologies that (a) are amenable to high throughput parallel synthesis of compound libraries and (b) result in high enantiomeric purity on the phosphorus atom.  Subsequently, we use or biologically active ligands to interrogate various biochemical pathways involved in cancer and neurodegeneration. Furthermore, we used our P-chiral phosphorus ligands to explore novel transition metal-catalyzed reactions and non-metal mediated organocatalytic reactions that are important in the multi-kilo production scale of human pharmaceuticals. Read more...

Chemical Biology
Structural Research
Positions

Post-Doctoral Fellow*

We are currently seeking applications for Post-Doctoral Research positions in Synthetic Organic Chemistry, Medicinal Chemistry and Biochemistry. Please see the respective links for application details.

Research Assistant*

We are currently seeking applications for a Research Assistant Position for Biochemical and Biological Evaluation Studies. Please see the link for application details.

PhD/MSc Graduate Students*

We have positions available for new graduate students to join our research group at the Department of Chemistry of McGill University. Some previous experience in research, preferably synthetic organic chemistry, is preferred but not absolutely required.

*Prof. Tsantrizos recognizes that the strength and competitive advantage of every team lie within its scientists and supports every member of her group in achieving his/her full potential. Her students and Post-Doctoral Fellows are challenged to take initiative in achieving outstanding results, work in a collaborative healthy environment that supports diversity amongst its members, networking with past members and leaders in industry, as well as close interactions with collaborators from other fields of biomedical research at McGill University.